Role of Cytokines in Wound Healing Following Wound Catheter Analgesia in Rats.

ABSTRACT:

Background

Local analgesia administered through a wound catheter is widely used for postoperative pain control, yet its effects on wound healing remain incompletely understood. This study examined how levobupivacaine alone or combined with meloxicam or buprenorphine influences inflammatory markers, angiogenesis, apoptosis, and transforming growth factor β1 (TGF-β1) expression during wound healing in rats.

Methods

Thirty Sprague Dawley rats were assigned to five groups: control, saline, levobupivacaine (L), levobupivacaine/meloxicam (L/MEL), and levobupivacaine/buprenorphine (L/BUP). Treatments were administered via a wound catheter for three days. Blood and skin samples were collected before surgery and on days 3, 10, and 21.

Results

Levobupivacaine combined with melo

SUBMITTER: Lipar M 

PROVIDER: S-EPMC12737617 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature