Chronic Chikungunya Arthritis in Northeastern Brazil: An Association with Very Severe Joint Pain and Lack of Correlation with <i>IL-6</i> and <i>TNFα</i> Gene Polymorphisms.

ABSTRACT: Chikungunya fever (CHIKF) affects thousands of people annually. Therefore, aspects involved in the pathogenesis of the disease must be further explored. In this study, we assessed the development of chronic chikungunya arthritis (CCA) and the single-nucleotide polymorphisms (SNPs) -174 G/C in the interleukin-6 (IL-6) gene and -308 G/A in the tumor necrosis factor alpha (TNFα) gene on CHIKF development in a population from Northeastern Brazil. A total of 313 blood and serum samples were collected. Of these, 102 were included in the cases group, 182 were included in the control group, and 29 were incorporated in the asymptomatic group. The DNA extraction and genotyping across real-time quantitative polymerase chain reaction (RT-qPCR) were performed. The data showed that 71.6% o

SUBMITTER: Maciel MSC 

PROVIDER: S-EPMC12737619 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature