Disease and Economic Burden Averted by Hib Vaccination in 160 Countries: A Machine-Learning Analysis.

ABSTRACT:

Background

Global immunization against Haemophilus influenzae type b (Hib) has expanded with Gavi support. We estimated health, economic benefits, equity and cost-effectiveness in 159 countries (1990-2021), and projected effects of future introduction in China.

Methods

We used a random forest model to simulate counterfactual scenarios without Hib vaccine introduction in 159 countries (1990-2021) and to project effects of Hib vaccine introduction in China over the next decade. Ten variables were sourced from the World Bank and WHO; Hib disease burden estimates were from the Global Burden of Disease Study 2021. We compared counterfactual and actual results to quantify benefits, equity, and cost-effectiveness. Extensive uncertainty analyses were performed.

Results

Betwee

SUBMITTER: Zhou D 

PROVIDER: S-EPMC12737673 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature