Genomic Characterization of a Class 2/1 Hybrid Integron-Driven Multidrug-Resistant <i>Proteus mirabilis</i> SH-8 of Swine Origin.

ABSTRACT: Objective:P. mirabilis is a Gram-negative rod-shaped bacterium. In this study, the SH-8 strain of P. mirabilis was isolated from swine-derived samples, and its antibiotic resistance genes (ARGs) and transmission mechanisms were systematically characterized. Methods: The minimum inhibitory concentrations (MICs) of strain SH-8 were determined by the broth microdilution method, with genomic features analyzed through whole-genome sequencing (WGS). Results:P. mirabilis SH-8 exhibited resistance to multiple antimicrobial agents. Its genome consists of a single chromosome (3,993,987 bp; GC content 38.8%) and one plasmid. WGS identified 21 distinct ARGs in this strain, along with a class 2/1 hybrid integron. Furthermore, a heatmap analysis of resistance ge

SUBMITTER: Wang X 

PROVIDER: S-EPMC12737719 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature