Immunogenicity of a Lipopolysaccharide <i>Brucella melitensis</i> Vaccine in Goats: An Exploratory Study.

ABSTRACT:

Background

Brucella melitensis is considered one of the most widespread zoonotic pathogens worldwide. Vaccination remains the most cost-effective strategy for controlling B. melitensis infection in small ruminants.

Methods

In this study, we evaluated the immunologic responses and protection against experimental challenge in 18 goats vaccinated with either lipopolysaccharide (LPS) from B. melitensis strain 16M (LPS alone), LPS of B. melitensis strain 16M and MONTANIDE™ ISA 61 VG adjuvant (Seppic; 50 Bd national, 92250 La Garenne-Colombes, France) (LPS + ISA 61 VG), or saline as a control.

Results

Goats (n = 6) vaccinated with LPS + ISA 61 VG had greater (p < 0.05) antibody responses than those that were nonvaccinated. Our data

SUBMITTER: Naseer A 

PROVIDER: S-EPMC12737732 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature