Co-Circulation of Tick-Borne <i>Bandaviruses</i> and <i>Orthonairoviruses</i> Across Humans, Livestock, and Rats in Pakistan: Serologic Evidence and Public Health Implications.

ABSTRACT: Tick-borne viruses (TBVs) pose significant public health and economic threats. Pakistan has endemic Crimean-Congo hemorrhagic fever virus (CCHFV), but evidence suggests broader TBV circulation. This study assessed the seroprevalence of thirteen TBVs (seven are members of the genus Orthonairovirus and six are members of the genus Bandavirus) in humans, livestock, and rats in Punjab, Pakistan. Serum samples (n = 794: 321 livestock, 253 human, and 220 rat) were collected from the Narowal, Lahore, and Faisalabad districts. Antibodies to viral NPs were detected using the luciferase immunoprecipitation system (LIPS). The overall seroprevalence was 19.14% (152/794); it was highest in livestock (27.10%), then humans (20.55%), and then rats (5.91%). The highest seroprevalence rates were 3.12% for C

SUBMITTER: Ammar M 

PROVIDER: S-EPMC12737738 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature