Global Prevalence and Cancer Risk of Epstein-Barr Virus and Human Papillomavirus Coinfection in Breast Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Breast cancer (BC) is the most frequently diagnosed malignancy and a dominant cause of cancer mortality among women worldwide. Alongside established risk factors, recent studies highlight oncoviruses like Epstein-Barr virus (EBV) and human papillomavirus (HPV) as potential contributors. However, their role and association with BC development is still debatable.

Study design and methods

This systematic review and meta-analysis involved two distinct approaches: one assessing the worldwide prevalence of EBV and HPV coinfection in BC patients and another investigating the association between such coinfection and BC risk. A systematic search across PubMed, Scopus, Web of Science, and Embase was conducted up to 5 May 2025. Studies using PCR to detect both viruses in bre

SUBMITTER: Karen AA 

PROVIDER: S-EPMC12737756 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature