Predictive Prognosis Value of CRP Measurement and CAR in Dogs Infected with Parvovirus.

ABSTRACT: Canine parvoviral (CPV) enteritis is frequently associated with systemic inflammatory response syndrome (SIRS), yet objective biomarkers for early detection remain limited. This study evaluated the diagnostic performance of C-reactive protein (CRP), albumin, and the CRP/albumin ratio (CAR) in 60 dogs (45 CPV-positive and 15 healthy controls). CRP and CAR were markedly higher in infected dogs, while albumin was significantly reduced (all p < 0.001). ROC analysis demonstrated excellent discrimination for SIRS, with AUC values of 0.87 for CRP and 0.86 for CAR and optimal ROC01 thresholds of 2.25 mg/dL and 1.23, respectively. The IDEXX CRP-based SIRS classification showed moderate agreement with the clinical reference (κ = 0.56), whereas a conditional inference tree and logistic regress

SUBMITTER: Maximino MM 

PROVIDER: S-EPMC12737769 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature