Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis.

ABSTRACT:

Background

Psoriasis, a chronic immune-mediated inflammatory skin disease, significantly impairs quality of life. Conventional treatments often pose safety risks or lack long-term efficacy. Dietary supplements show immunomodulatory and anti-inflammatory effects, but their adjunctive role in plaque psoriasis lacks a comprehensive comparison.

Methods

A network meta-analysis (NMA) of 21 randomized controlled trials (RCTs), involving 1,463 patients with plaque psoriasis, was conducted using eight international and Chinese databases up to March 3, 2025. Interventions included vitamin D, XP-828L, fish oil, selenium, probiotics, curcumin, and micronutrients. Primary outcomes were Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), physician global asses

SUBMITTER: Chen D 

PROVIDER: S-EPMC12738169 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature