EMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K-AKT signaling.

ABSTRACT:

Introduction

Triple negative breast cancer (TNBC) is characterized by high malignancy and poor prognosis due to the lack of a clear therapeutic target. The search for therapeutic targets for TNBC has always been a focus of research in the field of human oncology. Existing studies have shown that Epithelial membrane protein 1 (EMP1) is abnormally expressed in a variety of cancers and is closely related to the occurrence and development of tumors. However, the potential role and molecular mechanism of EMP1 in TNBC are still unclear.

Methods

In our study, we detected the expression levels of EMP1 in TNBC and analyzed the biological behavior of the TNBC cell line MDA-MB-231 after EMP1 expression changes.

Results

The results showed that the expression level of EMP1 in TNBC

SUBMITTER: Shu Z 

PROVIDER: S-EPMC12738301 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature