Intermittent fasting improves metabolic outcomes in metabolic syndrome: a systematic review and meta-analysis with GRADE evaluation.

ABSTRACT:

Background

Previous studies have demonstrated that intermittent fasting (IF) has garnered scientific attention and gained recognition for its beneficial effects on metabolic outcomes. However, the results are inconsistent. Accordingly, this systematic review and meta-analysis aimed to evaluate the effect of fasting on glycemic control, lipid profile, and inflammatory markers.

Methods

Databases such as PubMed, Embase, Cochrane, Scopus, and Web of Science were used to retrieve relevant studies published until September 2025. The quality of the included studies was evaluated using the Cochrane Risk-of-Bias 2 (RoB2) tool. Moreover, the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was employed to evaluate the quality of evidence.

Results</

SUBMITTER: Song Q 

PROVIDER: S-EPMC12738305 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature