Flow-controlled ventilation versus pressure-controlled ventilation in moderate to severe ARDS patients: a randomized crossover physiological study.

ABSTRACT:

Background

In mechanically ventilated patients with acute respiratory distress syndrome (ARDS) it is of great importance to prevent ventilator-induced lung injury (VILI) using lung protective ventilation. VILI has been associated with a high mechanical power (MP). Flow-controlled ventilation (FCV) could play a role in decreasing the risk of VILI by lowering the MP and preventing atelectrauma by a controlled expiration.

Objectives

To assess the difference in MP between FCV and pressure-controlled ventilation (PCV). Secondary aims were to explore the effect of FCV in terms of ventilation distribution and homogeneity, measured by electrical impedance tomography (EIT).

Methods

Randomized crossover physiological pilot study in ICU patients with a moderate to severe ARDS. P

SUBMITTER: van Oosten JP 

PROVIDER: S-EPMC12738392 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature