Na[¹⁸F]F PET/CT quantification in spondyloarthritis: comparative evaluation of SUV normalization approaches.

ABSTRACT:

Background

Sodium [¹⁸F]Fluoride Positron Emission Tomography (Na[¹⁸F]F PET) is a promising imaging biomarker for evaluating bone metabolism in spondyloarthritis (SpA) and other bone affecting diseases. Accurate quantification of tracer uptake is essential for assessing disease activity and treatment response. This study aimed to determine optimal simplified metrics for Na[¹⁸F]F uptake and evaluate their performance compared to net influx rate (K_i).

Results

A prospective study included 54 SpA patients undergoing Na[¹⁸F]F PET/CT scans at baseline and after 12 weeks of therapy. Dynamic PET in combination with venous blood sampling was analyzed to derive kinetic parameters, including K_i in 43 scans that included p

SUBMITTER: van der Heijden WRP 

PROVIDER: S-EPMC12738459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature