Luteolin regulates pyroptosis of triple-negative breast cancer cells through AKT signaling.

ABSTRACT: Triple-negative breast cancer (TNBC), the most aggressive molecular subtype of breast cancer, currently lacks effective therapeutic targets. While radiotherapy and chemotherapy remain the mainstay of treatment, therapy resistance frequently develops due to apoptosis evasion, leading to treatment failure. In this study, we demonstrate that luteolin, a naturally occurring flavonoid, effectively induces pyroptosis in TNBC cells through suppression of the AKT signaling pathway. Network pharmacology analysis and Western blot validation confirmed AKT pathway inhibition, with AKT agonists significantly reversing luteolin-induced pyroptosis. Mechanistically, luteolin upregulates the expression of GSDMD and NLRP3 while promoting the release of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), in

SUBMITTER: Junwei G 

PROVIDER: S-EPMC12738489 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature