Dissecting the role of SEPHS1 in shaping an immunosuppressive microenvironment to promote tumor progression.

ABSTRACT:

Background

Cancer immunotherapy has revolutionized the treatment landscape for multiple malignancies, particularly melanoma. However, therapeutic resistance remains common, highlighting the need to identify novel regulators of antitumor immunity. Selenium is an essential micronutrient that modulates redox homeostasis and immune function through its incorporation into selenoproteins. Yet, the immunological roles of selenium metabolism-related enzymes, especially Selenophosphate Synthetase 1 (SEPHS1), remain poorly defined.

Methods

We performed a comprehensive pan-cancer analysis using TCGA, CCLE, CPTAC, and cBioPortal datasets to evaluate the expression patterns and clinical relevance of selenium metabolism-related genes. A SELENOAMINO Score (SAS) was established to quantify

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12738508 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature