Decoding molecular signatures and identifying therapeutic targets in triple-negative breast cancer subtypes using omics and network analysis.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer. It is resistant to therapeutic applications, making it very difficult to manage. Most patients continue to receive chemotherapy. The main challenges in treating TNBC arise from its histopathological, transcriptomic, and genomic heterogeneity. While subtype classification was once essential for understanding TNBC's diverse behavior, it is now crucial to thoroughly evaluate the molecular characteristics of each subtype to improve TNBC management. Our study employed a multi-omics approach utilizing transcriptomic data to compare TNBC subtype-specific cell lines with normal breast epithelial cell lines. Our goal was to find out essential transcription factors (TFs) regulating cancer-related pathways, subtype-spe

SUBMITTER: Sanyal D 

PROVIDER: S-EPMC12738556 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature