Modular programming of interaction and geometric specificity enables assembly of complex DNA origami nanostructures.

ABSTRACT: Self-assembly of nanoscale building blocks with programmable geometries and interactions offers a powerful route to engineer materials that mimic the complexity of biological structures. DNA origami provides an exceptional platform for this purpose, enabling precise control over subunit shape, binding angles, and interaction specificity. Here we present a modular DNA origami design approach to address the challenges of assembling geometrically complex nanoscale structures, including those with nonuniform curvatures. This approach features a core structure that completely conserves the scaffold routing across different designs and preserves more than 70% of the DNA staples between designs, dramatically reducing both cost and effort, while enabling precise and independent programming of subu

SUBMITTER: Saha R 

PROVIDER: S-EPMC12738586 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature