Identification of conserved canonical marker genes in human and mouse adrenal glands using Visium spatial transcriptomics.

ABSTRACT: The adrenal glands are essential endocrine organs whose cortex and medulla maintain systemic homeostasis and mediate stress responses via steroid hormone and catecholamine secretion. Despite anatomical and functional similarities between human and mouse adrenal glands, notable species-specific differences exist. Here, we leveraged spatial transcriptomics (10× Genomics Visium) to comprehensively map gene expression in adult human and mouse adrenal glands, aiming to identify canonical marker genes conserved across species. The analysis was based on a 31-year-old female human sample (GEO dataset) and four 10-week-old male CD-1 mice. Human adrenal sections were processed using optimal cutting temperature (OCT) embedding, whereas mouse adrenal sections were processed as formalin-fixed paraffin-

SUBMITTER: Blatkiewicz M 

PROVIDER: S-EPMC12738614 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature