Unveiling the multitarget mechanism of Liuwei Dihuang decoction in autism spectrum disorder via network pharmacology and molecular docking.

ABSTRACT: Liuwei Dihuang decoction (LW) is used for paediatric autism spectrum disorders (ASD) treatment, but its mechanism of action is unclear. This study aims to provide clinical evidence for LW in treating ASD in children and investigate its mechanism through network pharmacology, microarray analysis, and molecular docking. A retrospective review of 80 clinical cases of children with ASD and the therapeutic effect of LW was conducted. Drug-disease co-expressed genes were used to construct PPI network maps. The active ingredients of LW were obtained from the TCMSP, CNKI, and PubMed, with screening criteria of OB ≥ 30% and DL ≥ 0.18. Disease targets were sourced from the GeneCards, OMIM, and DisGeNET databases. Core targets were further analyzed using GO and KEGG. Microarray data were employed to

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12738649 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature