Advancing pyrolysis-gas chromatography-mass spectrometry for the accurate quantification of micro- and nanoplastics in human blood.

ABSTRACT: Quantification of micro- and nanoplastics (MNPs) in human samples is essential for accurately assessing human exposure and understanding the potential health impacts of these pervasive pollutants. Blood plays a key role in revealing potential MNPs exposure and its health impacts. The detection of MNPs in human blood, however, is analytically challenging due to the complex composition of the sample and the limited availability of sensitive analytical methods. Pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) using Selected Ion Monitoring (SIM) has been widely used to quantify MNPs in human blood. In this work the analytical approach was improved by employing full scan data acquisition. The mass concentration of six polymers widely used in plastic materials - poly(methyl methacrylate

SUBMITTER: Nardella F 

PROVIDER: S-EPMC12738653 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature