Exploring natural AMPK activators from bioactive compounds in fenugreek and oyster mushroom for management of type 2 diabetes.

ABSTRACT: Oral antidiabetic drugs mainly act by stimulating pancreatic β-cells, but prolonged stimulation may lead to exhaustion and impaired insulin secretion. In contrast, AMP-activated protein kinase (AMPK) lowers blood glucose through an insulin-independent pathway, offering therapeutic potential. This study aims to identify AMPK activators in oyster mushrooms and fenugreek using GC-MS and bioinformatics analysis. The bioactive compounds in both samples were identified through GC-MS analysis. Molecular docking, pharmacokinetics, drug-likeness, toxicity, and molecular dynamics simulation (MDS) were employed to evaluate the therapeutic potential of the identified phytochemicals. The results showed that the ester class of compounds was the most abundant in both fenugreek and oyster mushroom extract

SUBMITTER: Mazumdar S 

PROVIDER: S-EPMC12738695 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature