The moderating role of diet and physical activity in insulin resistance and immunometabolic depression.

ABSTRACT: Insulin resistance (IR) and atypical depression share an immunometabolic pathway and present major health risks. Although IR has been associated with atypical depression, its link to immunometabolic depression (IMD) symptoms is less understood. Lifestyle factors like physical activity (PA) and diet may mitigate these conditions through anti-inflammatory and antidiabetic effects. This study examines how lifestyle factors moderate the IR-IMD relationship. We conducted a cross-sectional analysis using baseline data from the mPRIME study (n = 124). IR was measured via HOMA-IR, and IMD symptoms (hypersomnia, hyperphagia, loss of energy, tiredness) were assessed using a composite score derived from four Beck Depression Inventory-II items that have been previously linked to immunometabolic altera

SUBMITTER: Gruber JR 

PROVIDER: S-EPMC12738732 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature