Impact of particle size and surface modifications on the neurotoxic potential of copper oxide nanoparticles.

ABSTRACT: Copper oxide (CuO) nanoparticles (NPs) have widespread applications in electronics, energy storage, and healthcare domains owing to their high surface-to-volume ratio, catalytic activity, and anti-bacterial and anti-microbial properties. However, the health hazard of direct CuO exposure to humans has raised safety concerns. CuO NPs can cross the blood-brain barrier, access the central nervous system, and trigger neurotoxicity. Previous studies have investigated the neurotoxicity of CuO NPs. However, the effects of different sizes and comparable size NPs with and without surface coating have not been previously reported. In this study, two differentially sized NPs (CuO-25 and CuO-48 NPs) and one polyvinylpyrrolidone-coated NP (CuO-P NPs; 46 nm) were synthesized and characterized. The neurot

SUBMITTER: Suthar JK 

PROVIDER: S-EPMC12738751 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature