Evaluation of cross-functional antibody responses elicited by a four-component GMMA Shigella vaccine.

ABSTRACT: Shigella is a major cause of morbidity and mortality in children in low- and middle-income countries. The O-antigen (OAg) component of the lipopolysaccharide is considered a protective antigen, however, their diversity challenges vaccine development, since more than 50 OAg serotypes have been identified. No licensed vaccine against shigellosis is available. A 4-component GMMA-based vaccine, altSonflex1-2-3, delivering S. sonnei and S. flexneri 1b, 2a and 3a OAg has been developed. Coverage is expected against non-vaccine serotypes, due to cross-reactivity, mediated by structural similarities among S. flexneri OAg. The vaccine is currently being tested in phase I and II clinical trials. In this work, sera from mice, rats, and rabbits injected with altSonflex1-2-3 were analyzed for their abi

SUBMITTER: Caradonna V 

PROVIDER: S-EPMC12738785 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature