Metabolic profiling revealed alterations associated with sedentary work in bus drivers.

ABSTRACT: Sedentary behavior in the workplace has emerged as a critical public health concern, with bus drivers representing a high-risk group due to prolonged compulsory sitting. This study aimed to investigate metabolic alterations associated with sedentary work in professional bus drivers compared to active controls. A total of 60 bus drivers and 60 sanitation workers (matched for age, sex, and lifestyle) as controls were enrolled. Fasting serum samples of the subjects were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for metabolomic profiling. Demographic data and biochemical parameters were also collected. Metabolomic analysis identified 322 metabolites, with 57 differential metabolites (52 up-regulated and 5 down-regulated) in the bus drivers rel

SUBMITTER: Lin D 

PROVIDER: S-EPMC12738792 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature