Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation.

ABSTRACT: The maintenance of adult tissue homeostasis is dependent on the functional cross-talk between stem cells (SCs) and tissue-resident immune cells. This reciprocal relationship is also essential for tissue organogenesis during early life. The skin harbors a relatively large population of regulatory T cells (Tregs) that accumulate within the first two weeks after birth. A functional role for early skin seeding Tregs (ETregs) during the first week of life is currently unexplored. Here, we show that skin Tregs are detected as early as postnatal day 3 (P3) and enter a dynamic flux of activation marker expression. Punctual ETreg depletion from P6-P8, but not later, resulted in defective hair follicle (HF) melanocyte SC (MeSC) mediated skin pigmentation in juvenile life. Transcriptomic analysis of

SUBMITTER: Cho I 

PROVIDER: S-EPMC12738793 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature