Characteristics of CD103⁺CD8⁺ T cells in the spleen of <i>Plasmodium yoelii</i> NSM-infected mice.

ABSTRACT:

Background

CD8⁺ T cells play a critical role in controlling Plasmodium infection. CD103, an integrin composed of αE and β7 subunits, is widely recognized as a cell surface marker for tissue-resident memory T (TRM) cells and tumor-infiltrating lymphocytes (TILs).

Methods

In this study, a Plasmodium infection model was constructed by intraperitoneally injecting 10⁶ infected red blood cells (iRBCs) into C57BL/6 mice. CD45⁺ cells in the spleen of naïve and infected mice were sorted and subjected to single-cell RNA sequencing (scRNA-seq). The content, activation, and function of CD103⁺CD8⁺ T cells were detected using flow cytometry. qPCR and dual-luciferase reporter assays were performed to find the key transcri

SUBMITTER: Pan X 

PROVIDER: S-EPMC12738814 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature