IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19.

ABSTRACT: CD25 (IL-2 receptor alpha chain) is a key component of the high-affinity receptor for the IL-2 cytokine and regulates the proliferation, survival, and differentiation of immune cells. The expression of CD25 has been demonstrated in basophils of patients with allergic diseases such as asthma. Previous studies have shown that IL-3 priming leads to increased CD25 expression in basophils. However, other potential stimuli that can regulate the CD25 expression on basophils and their possible biological consequences remain poorly understood. Here, we demonstrate that the IL-33 cytokine, a critical driver of type 2 immunity and allergic inflammation, significantly upregulates CD25 expression on IL-3-primed human basophils. Despite high levels of CD25 expression and its ability to capture IL-2 cyto

SUBMITTER: Retnakumar SV 

PROVIDER: S-EPMC12738815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature