Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223-associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure.

ABSTRACT:

Background

Pyroptotic signaling involving nuclear factor-kappa B (NF-κB) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) has been implicated in chronic heart failure (CHF). Xin-Fu-Kang (XFK) is a nine-herb formula used clinically for CHF with "qi deficiency and blood stasis." Although cardioprotective effects have been reported, it remains unclear whether XFK modulates myocardial pyroptotic signaling via miR-223-dependent regulation of NF-κB.

Methods

A CHF model was established by permanent left anterior descending coronary artery (LADCA) ligation in rats, and an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) injury model was generated in H9c2 cardiomyocytes. Cardiac structure and function were assessed by transthoracic echocardiography and h

SUBMITTER: Ye Z 

PROVIDER: S-EPMC12738884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature