Molecular insights into Atorvastatin's role in delaying intervertebral disc degeneration.

ABSTRACT:

Introduction

This study aimed to investigate the molecular mechanisms and effects of atorvastatin (Ator) in delaying intervertebral disc degeneration (IDD), with a particular focus on its role in modulating oxidative stress and apoptosis in nucleus pulposus cells (NPCs) via the Nrf2 signaling pathway.

Methods

In vitro, rat NPCs were treated with different concentrations of atorvastatin, and the optimal concentration was determined using the Cell Counting Kit-8 (CCK-8) assay. Reactive oxygen species (ROS) levels were measured using a ROS detection kit, while apoptosis was evaluated by flow cytometry and TUNEL assays. Western blotting was performed to assess the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), its downstream antioxidant proteins, and ap

SUBMITTER: Li Y 

PROVIDER: S-EPMC12738912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature