Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level.

ABSTRACT: Endogenous cardiotonic steroids (CTS), which are specific ligands of Na,K-ATPase, have been detected not only in blood plasma but also in cerebrospinal fluid and in the brain tissue. Consequently, the role of CTS in the central nervous system has gained increasing relevance. Na,K-ATPase serves not only as a receptor for CTS but also as a target for beta-amyloid (Aβ₄₂). Previously, we demonstrated that ouabain binding to Na,K-ATPase prevents Aβ₄₂-induced activation of Src kinase and the subsequent change in the level of the amyloid precursor protein (APP) in human neuroblastoma SH-SY5Y cells. In this study, we characterized the effects of other CTS-marinobufagenin, bufalin, and digoxin, on APP level in these cells. We found that, unlike ouabain, bufalin and digoxin inc

SUBMITTER: Petrushanko IY 

PROVIDER: S-EPMC12738930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature