Role of HMGB1 in ischemia/reperfusion injury in a rat model of myocardial infarction.

ABSTRACT: Myocardial infarction (MI) results from the abrupt interruption of coronary blood flow, leading to ischaemia and cardiac tissue necrosis. High mobility group box 1 (HMGB1), a damage-associated molecular pattern, plays a dual role in MI, offering protection or causing damage depending on the cellular redox status, timing of its activity, and location. The aim of this study was to analyse the effects of an anti-HMGB1 protein on certain biochemical parameters of individual myocardial zones, the infarct zone (IZ), injured zone (INZ), and noninfarct zone (NIZ), after MI. Twelve-week-old male WKY rats were randomly divided into 3 experimental groups: 1. control (sham), 2. MI (MI), and 3. MI plus anti-HMGB1 treatment (MI + aHMGB1). MI was induced via 20-min ligation of the left descending coronar

SUBMITTER: Cebova M 

PROVIDER: S-EPMC12739116 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature