Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics.

ABSTRACT: Understanding genetic architecture across ancestries through genetic correlation analysis is critical for determining the degree to which genetic factors underlying diseases or complex traits are shared or differ among populations. Current methods for genetic correlation analysis primarily rely on method of moments approaches and focus on estimating the global genetic correlation across the entire genome. However, these methods often overlook important local genomic complexities and inadequately model the intricate linkage disequilibrium (LD) structures that vary substantially across ancestries. Here, we present Logica (local genetic correlation across ancestries), a method specifically designed to estimate local genetic correlations across ancestries and in admixed populations. Logica emp

SUBMITTER: Gao B 

PROVIDER: S-EPMC12739644 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature