The CCL11-CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia.

ABSTRACT: In ischemic stroke (IS), the programmed death of neurons is a key factor contributing to poor prognosis and neurological dysfunction. Recently, it has been discovered that necroptosis, as a form of programmed cell death, promotes neuroinflammatory damage after IS; however, its mechanism is still unclear. Recent studies have shown that CCL11, as an eosinophil chemokine, may induce neuronal cytotoxicity by triggering the production of reactive oxygen species (ROS) in microglia. Meanwhile, CCR3, serving as the major functional membrane receptor target of CCL11, plays a crucial role in transducing CCL11 signals. This study establishes a mouse model of IS using permanent middle cerebral artery ligation (pMCAL) and utilizes methods such as Western blot (WB), quantitative polymerase chain reactio

SUBMITTER: Yin H 

PROVIDER: S-EPMC12739800 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature