Distinct gut microbiome profiles in Korean systemic lupus erythematosus patients.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with systemic inflammation and multi-organ involvement. Emerging evidence suggests that gut microbiota dysbiosis may contribute to its immunopathogenesis.

Objective

This study aimed to characterize gut microbial composition and diversity in Korean SLE patients and evaluate associations with clinical features.

Methods

Fecal samples from 157 SLE patients and 50 healthy controls (HC) were analyzed using 16S rRNA gene sequencing. Alpha and beta diversity metrics were assessed, and taxonomic differences were analyzed. Subgroup comparisons were conducted based on lupus nephritis (LN) status and disease activity. Functional predictions were inferred using PICRUSt2.

Results

SLE patients e

SUBMITTER: Park Y 

PROVIDER: S-EPMC12739845 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature