Survival implications of the age-associated tumor and normal adjacent tissue microbiome among colorectal cancer patients.

ABSTRACT:

Background

CRC incidence is rising among individuals younger than 50 years of age, with significant gaps in our understanding of the composition of the tissue microbiome across the age spectrum. The microbiome of tumors and normal adjacent tissue among colorectal cancer (CRC) patients may provide critical insights into the tumor microenvironment and CRC prognosis.

Methods

We characterized the tumor and normal adjacent tissue microbiome of early-onset (EoCRC, n = 46) and frequency-matched later-onset (LoCRC, N = 101) CRC patients who underwent surgery at Moffitt Cancer Center. We extracted DNA from archival tissue from 147 patients and sequenced the 16 S rRNA gene. We estimated the relative abundance of a priori and exploratory bacteria and alpha and beta diversity. We used m

SUBMITTER: Morales MFG 

PROVIDER: S-EPMC12739855 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature