Demyelination-related pain: role of lysophosphatidic acid in satellite glial cell-neuron crosstalk.

ABSTRACT:

Background

Demyelination diseases are characterized by injury to large (A-type) myelinated nerve fibers, and by secondary damage to small (C-type) sensory fibers, which leads to chronic pain symptoms, such as allodynia. The mechanisms underlying the interactions between the two fiber types are not clear. This study aims to investigate the role of lysophosphatidic acid (LPA) signaling in satellite glial cells (SGCs) within the dorsal root ganglia (DRG) in demyelination-induced chronic pain.

Methods

A demyelination model was established by injecting cobra venom into the tibial nerve of 8-10-week-old Sprague-Dawley rats to selectively damage A-fiber myelin. Myelin morphology was observed via transmission electron microscopy (TEM) at 1, 3, 7, and 14 days post-injection. Pain beh

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12739857 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature