Nutritional and inflammatory biomarkers in predicting spontaneous anastomotic leakage closure following enterocutaneous fistula resection: the role of postoperative CRP-lymphocyte ratio.

ABSTRACT:

Background

To determine the correlation between the C-reactive protein-lymphocyte ratio (CLR) and the spontaneous resolution of anastomotic leakage (AL) subsequent to the resection of enterocutaneous fistulas (ECF).

Methods

In this retrospective cohort analysis, we examined adult patients who experienced AL following ECF resection from January 2019 to January 2024. Observations continued for 90 days post-surgery, during which CLR values were recorded at designated intervals. The relationship between CLR and the spontaneous resolution of leakage by 30 and 90 days was evaluated using logistic regression and restricted cubic splines.

Results

Out of 107 participants, 35 (32.7%) exhibited spontaneous resolution of leakage within 30 days, while 90 (84.1%) did so by the 90-d

SUBMITTER: Yu T 

PROVIDER: S-EPMC12739880 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature