Development and validation of age- and sex-specific reference intervals for serum vitamin B5 in Henan pediatric population by LC-MS/MS.

ABSTRACT:

Background and objective

Reference intervals (RIs) for serum vitamin B5 (pantothenic acid, B5) specific to the Henan pediatric population have not been established. Current clinical practice, in China continues to rely on reference thresholds derived from international populations. However, these generalized intervals may lack diagnostic accuracy and relevance when applied to domestic children. This study aims to establish age- and sex-specific RIs for serum B5 in Henan children aged 1-17 years, thereby enhancing the reliability of clinical assessments and nutritional evaluations.

Methods

This cross-sectional study involved 1,998 healthy children who underwent routine physical examinations between January 2022 and March 2025. Serum B5 concentrations were quantified using liq

SUBMITTER: Luan Y 

PROVIDER: S-EPMC12739956 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature