Age-Dependent Metabolomic Signatures of Dietary Restriction in Mice.

ABSTRACT: Caloric (CR) or dietary (DR) restriction improves health and extends lifespan in multiple species. However, the beneficial effects of DR may diminish if introduced late in life, emphasizing the importance of timing for promoting healthspan and avoiding adverse outcomes. Using a metabolomics approach, we investigated the metabolic responses in plasma, liver, and kidney of mice on acute and chronic DR at various ages. Two hundred and five mice including young (2-month-old; n = 72), middle-aged (6-month-old; n = 76), and old (17-month-old; n = 57) mice for DR were involved. No significant metabolic distinctions were observed during acute DR across different ages. Throughout chronic DR, hepatic glucose, glycogen, and glutathione levels-all of which decreased with age-were elevated in all mice,

SUBMITTER: Lee JS 

PROVIDER: S-EPMC12740100 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature