Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the EV-idence?

ABSTRACT:

Background

Extracellular vesicles (EVs) represent a promising cell-free regenerative therapy. Deciphering their mode and mechanism of action comes with technical and biological challenges. This scoping review presents a complementary perspective to reviews that synthesized EV therapeutic strategies in intervertebral disc (IVD) degeneration. It intends to create awareness of the minimal experimental requirements defined by the International Society for Extracellular Vesicles (MISEV). These have been established to facilitate robust and reproducible protocols in the rapidly expanding EV field, aiming to allow comparative studies, improve reproducibility, and interpretability.

Methods

The MISEV were tailored with IVD-related considerations. Within the timeframe 2016-2025, 129 a

SUBMITTER: Corraini D 

PROVIDER: S-EPMC12740142 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature