Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression.

ABSTRACT: Multiple sclerosis (MS) is a severe autoimmune disorder that wreaks havoc on the central nervous system, leading to a spectrum of motor and cognitive impairments. There is no cure, and current treatment strategies rely on broad immunosuppression, leaving patients vulnerable to infections. To address this problem, our approach aims to induce antigen-specific tolerance, a much-needed shift in MS therapy. We have engineered a tolerogenic therapy consisting of spray-dried particles made of a degradable biopolymer, acetalated dextran, and loaded with an antigenic peptide and tolerizing drug, rapamycin (Rapa). After initial characterization and optimization, particles were tested in a myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis model of MS. Represe

SUBMITTER: Stiepel RT 

PROVIDER: S-EPMC12740341 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature