Association Between Respiratory Viral Infection and Peripheral T Lymphocyte Subsets in Elderly Patients With Acute Exacerbation of Bronchiectasis.

ABSTRACT:

Background

Respiratory viral infections are increasingly recognized as important triggers of acute exacerbations in bronchiectasis (AEB); the virological profiles and immunological mechanisms in elderly patients remain poorly characterized.

Methods

A prospective cohort of 102 elderly bronchiectasis patients was followed for 12 months. Upon AEB occurrence, nasopharyngeal swabs were obtained for multiplex fluorescence quantitative PCR detection of eight respiratory viruses, while peripheral blood samples were analyzed for T lymphocyte subsets by flow cytometry. Clinical characteristics, inflammatory markers, and T cell subsets were compared between virus-positive and virus-negative groups at first AEB; ROC curve analysis evaluated the predictive value of T cell subsets for vir

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12740622 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature