Relationship between intrahemispheric and interhemispheric connectivity of the language network and language improvement in subacute post-stroke aphasia.

ABSTRACT: Speech production and comprehension are coordinated by a large-scale language network. The dynamic balance of intrahemispheric and interhemispheric connectivity within this network is essential for normal language processing. Stroke often significantly disrupts both the functional integrity and dynamic balance of the language network, leading to language deficits (aphasia). However, the brain's adaptive potential to compensate for lesions in post-stroke aphasia (PSA) remains incompletely understood. A key unresolved question is whether recovery of language function in PSA is primarily facilitated by compensatory mechanisms within the left hemisphere, increased recruitment ("upregulation") in the right hemisphere, or both. Building on prior research, we defined a language network encompassi

SUBMITTER: Xie X 

PROVIDER: S-EPMC12740746 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature