HMCN1 as a conserved biomarker of epithelial-mesenchymal transition: a cross-cancer analysis.

ABSTRACT:

Background

The extracellular matrix (ECM) critically regulates tumor progression, but the systematic role of its large constituent hemicentin-1 (HMCN1) across cancers remains poorly defined. Although implicated in cell invasion and migration, a comprehensive pan-cancer understanding of HMCN1 is lacking.

Methods

We performed an integrative multi-omics analysis of HMCN1 across 33 cancer types using data from TCGA, GTEx, and CPTAC. Based on prominent functional importance in bone tumors, osteosarcoma was selected for functional validation. In vitro experiments, including knockdown and overexpression, were conducted to assess effects on migration and invasion.

Results

HMCN1 was frequently upregulated in tumors and associated with poor prognosis

SUBMITTER: Leng Y 

PROVIDER: S-EPMC12740748 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature