Cannabigerol Exerts <i>In Vivo</i> and <i>In Vitro</i> Anti-Inflammatory Effects via Inhibition of the MAPK and NF-κB Pathways.

ABSTRACT: Cannabis sativa L. has a long history of use and contains more than 80 cannabinoids. However, although cannabigerol (CBG), which acts as a biosynthetic precursor of its most abundant phytocannabinoids, has anti-inflammatory effects, the exact mechanism of action remains underexplored. In this study, we explored the anti-inflammatory potential of CBG to assess its potential for therapeutic and industrial applications. CBG was extracted from the cannabis cultivar 'Pink Pepper' In vitro assays were performed via RAW 264.7 mouse macrophages stimulated with lipopolysaccharide, and in vivo efficacy was evaluated through a carrageenan-induced paw edema mouse model to confirm the activity of CBG in acute inflammation. Nitric oxide production, mRNA, and protein expression of in

SUBMITTER: Kim JH 

PROVIDER: S-EPMC12740850 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature