Gut and oral microbiome profiles in patients with obesity and ischemic heart disease.

ABSTRACT:

Background

Ischemic heart disease (IHD) and obesity are major contributors to global mortality. Both conditions are linked to systemic inflammation, dyslipidemia, and microbiota alterations. This study examines the relationship between the composition of the gut and oral microbiota, obesity, and IHD to gain insight into the interconnections between these factors.

Methods

The study included 182 participants divided into four groups based on obesity and IHD status. Anthropometric and biochemical analyses were performed. Oral and gut microbiomes were analyzed using 16S rRNA sequencing.

Results

Obesity and IHD were associated with distinct microbiota compositions. Obesity-IHD subjects showed elevated levels of gut Streptococcus, Intestinibacter, alongside reduced <

SUBMITTER: Starodubova A 

PROVIDER: S-EPMC12740868 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature