Association of early and mid-pregnancy maternal serum uric acid with hypertensive disorders of pregnancy.

ABSTRACT:

Objective

To examine association between maternal serum uric acid (UA) measured during gestational 4-24 weeks and the subsequent development of hypertensive disorders of pregnancy (HDP) in a large Chinese cohort.

Methods

This historical cohort study included 84,298 singleton pregnancies registered at Shanghai First Maternity and Infant Hospital (2013-2022). Serum UA was measured before 24 weeks of gestation. Participants with pre-existing hypertension or incomplete data were excluded. Generalized additive models (GAMs) and multivariable logistic regression analyses were used to assess nonlinear and independent associations between UA levels (quartiles and continuous values) and risks of gestational hypertension (GH), preeclampsia (PE), and overall HDP cases, adjusting for ma

SUBMITTER: Zou C 

PROVIDER: S-EPMC12740876 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature