Epidemiological, clinical characteristics and prognostic factors analysis of adult patients with hemophagocytic lymphohistiocytosis in a Chinese hospital.

ABSTRACT:

Background

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome characterized by immune dysregulation and excessive inflammation. Although diagnostic criteria and treatment protocols of HLH are well-established for pediatric populations, managing adult HLH remains challenging.

Methods

We conducted a single-center retrospective cohort study with adult HLH using data from the First Affiliated Hospital with Nanjing Medical University (January 2015-November 2023). Patient demographics, triggers, and outcomes were analyzed. Trends in case volume, diagnostics, treatments, and 30-day mortality were assessed using Sen's slope estimator. To evaluate the COVID-19 pandemic's impact, we compared pre-/post-January 2020 data. Logistic regression, Kaplan-Meier s

SUBMITTER: Xie M 

PROVIDER: S-EPMC12740881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature