Remarkable response to pembrolizumab in PD-L1 overexpressing (≥ 50%) NSCLC and extracranial abscopal effect induced by brain radiotherapy: a case report.

ABSTRACT:

Background

Lung cancer remains the most prevalent malignant neoplasm worldwide, with adenocarcinoma being among its most frequent subtypes. The brain is a common metastatic site in patients with lung adenocarcinoma, often associated with poor prognosis, and brain radiotherapy is the standard recommended treatment. However, the occurrence of an extracranial abscopal effect following brain-directed radiotherapy is rare due to the brain's unique immune microenvironment.

Case description

We present the case of a 64-year-old Asian male who was admitted with complaints of "right-sided hemiplegia, reduced muscle strength, impaired ambulation, headache, projectile vomiting, and fatigue persisting for five days". Magnetic Resonance Imaging (MRI) of the brain revealed multiple space-o

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12740888 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature